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Rare Genetic Cholesterol You Should Know: How Lipoprotein(a) Impacts Heart Health—and Possibly Dental Outcomes

Understanding Lipoprotein(a) – A Silent Heart Risk Factor

Lipoprotein(a), or Lp(a), is a genetically determined type of cholesterol that has been under the spotlight in cardiovascular research. While first identified in 1963, recent studies have highlighted its strong association with increased heart disease and stroke risk.

Much like low-density lipoprotein (LDL), Lp(a) contributes to plaque buildup in arteries, a process known as atherosclerosis. What makes Lp(a) especially important? Unlike diet-related cholesterol, Lp(a) levels are inherited. About 1 in 5 people worldwide have elevated Lp(a), which may go undetected in routine cholesterol tests.

📌 A simple blood test (non-fasting required) can measure Lp(a), yet most standard lipid panels do not include it.
👉 Experts recommend everyone get their Lp(a) checked at least once in a lifetime.

  • Normal Lp(a): Under 30 mg/dL

  • ⚠️ Elevated Risk: Over 50 mg/dL

Currently, no medication specifically lowers Lp(a), so the focus remains on managing overall cardiovascular risk:

  • Controlling blood pressure, blood sugar, and LDL cholesterol

  • Following a heart-healthy lifestyle with balanced diet and regular physical activity

  • Considering omega-3s and vitamins that support cardiovascular health (after consulting your physician)


Why This Matters for Dentistry: The Oral-Systemic Link

Dental professionals should be aware that elevated Lp(a) may influence systemic inflammation, including vascular health, wound healing, and periodontal disease. Integrating medical history reviews that include cardiovascular risk markers like Lp(a) can guide more personalized dental care—especially in patients with a history of stroke, heart disease, or family history of hypercholesterolemia.

Takeaway for Dental Teams:
Consider flagging patients with known cardiovascular issues and encouraging them to discuss Lp(a) testing with their physician. Early risk detection means better interdisciplinary care—and healthier outcomes for both mouth and heart.


🔗 Let’s Make the Connection:

Your mouth is not separate from your body. Understanding hidden risk factors like Lipoprotein(a) is a step toward proactive, whole-body dentistry.

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